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"We found out that the Thimeresol would be toxic down to – not grams, not mg's, not mcgs, but nano grams – parts per billion – which was almost unbelieveable. This was published in the American Journal Medical Society, in the New York Academy Sciences and in the Journal For the Chemical Speciality Manufactures Association and it didn't make wave, there wasn't even a ripple – no one seemed to care." – Dr Frank P Engley PhD – Blue Ribbon Panel Member 1948 AMA meeting regarding Thimeresol's concerns
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Antidepressants have been recognized as potential inducers of mania and psychosis since their introduction in the 1950s. Klein and Fink1 described psychosis as an adverse effect of the older tricyclic antidepressant imipramine. Since the introduction of Prozac in December, 1987, there has been a massive increase in the number of people taking antidepressants. Preda and Bowers2 reported that over 200,000 people a year in the U.S. enter a hospital with antidepressant-associated mania and/or psychosis. The subsequent harm from this prescribing can be seen in these 4,800+ stories.